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Highest Quality | For Research Use Only

Buy AICAR Peptide France

AICAR, or 5-aminoimidazole-4-carboxamide ribonucleotide, is a peptide that has gained attention as a promising therapeutic agent with diverse potential applications, particularly in conditions related to muscle function and metabolism. AICAR peptide acts primarily as an AMPK activator (AMP-activated protein kinase),a regulator of cellular energy homeostasis which plays a crucial role in glucose and lipid metabolism.

In addition to its effects on muscle metabolism, AICAR also exhibits cardioprotective properties. It has been shown to reduce the size of myocardial infarction and improve post-ischemic heart function, potentially via the activation of AMPK and the subsequent inhibition of apoptosis.

AICAR is also being studied as a possible treatment for diabetes, autoimmune diseases, and other inflammatory conditions.

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Potential Benefits of AICAR Peptide

  • AMPK Activation: AICAR, short for 5-Aminoimidazole-4-carboxamide ribonucleotide, is known to stimulate AMP-activated protein kinase (AMPK) activity. AMPK is a key regulator of cellular energy homeostasis, which makes AICAR beneficial in metabolic regulation [1].
  • Enhanced Endurance: Studies have shown that AICAR peptide can enhance endurance in mice by transforming fast-twitch muscle fibers into the more energy-efficient, fat-burning, slow-twitch type [2].
  • Cardioprotection: AICAR has demonstrated cardioprotective properties. It has been found to limit infarct size during ischemia and improve post-ischemic heart function [3].
  • Neuroprotection: Research suggests that AICAR has potential neuroprotective effects. It may mitigate neuronal damage after incidents such as stroke or spinal cord injury [4].
  • Anti-Diabetic Effects: AICAR peptide has been shown to improve insulin sensitivity, presenting potential benefits for managing type 2 diabetes [5].
  • Cancer Therapy Potential: While more research is needed, studies suggest AICAR might have potential in cancer therapy due its ability to inhibit cell proliferation and induce apoptosis in certain cancer cell lines [6].
  • Inflammation Modulation: AICAR has been observed to exert anti-inflammatory effects, which may have significant implications in the treatment of chronic inflammatory diseases [7].

References

  1. https://www.researchgate.net/ publication/6128312
  2. Narkar VA, Downes M, Yu RT, et al. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008;134(3):405-415. doi:10.1016/j.cell.2008.06.051
  3. Yin T, Sandhu G, Wolfgang CD, et al. Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney. J Biol Chem. 1997;272(32):19943-19950. doi:10.1074/jbc.272.32.19943
  4. https://pubmed.ncbi.nlm.nih.gov/22198598/
  5. https://pubmed.ncbi.nlm.nih.gov/12351423/
  6. https://pubmed.ncbi.nlm.nih.gov/17638885/
  7. https://pubmed.ncbi.nlm.nih.gov/19050283/

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