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LL-37, also known as CAP-18, is a one-of-a-kind human peptide that belongs to the cathelicidin antimicrobial peptide family. LL-37 has wide antimicrobial activity against a variety of pathogens, including bacteria, viruses such as HIV, fungi, and even those found in biofilms.
Pre Mixed Cartridge and Kit:
Single Mixed Cartridges (1,2 & 3) Come with:
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605 in stock
This product is intended for research purposes only. To be used by trained professionals only.
LL-37, also known as CAP-18, is a human peptide that belongs to the cathelicidin antimicrobial peptide family. It modulates innate immune responses and prevents the production of bacterial biofilms in the human immune system [1].
During an immunological response, this multifunctional peptide can be up-regulated. Its skills include the ability to protect mice from deadly endotoxemia [2], indicating its potential for therapeutic uses in infections and sepsis. It has also been shown in France studies to inhibit the production of bacterial biofilms, which are organised communities of bacteria that contribute to chronic infections [3].
The immunomodulatory activity of LL-37 (cap-18) pre mixed peptide has been investigated in the context of autoimmune disorders and viral infections. It has been discovered that patients with moderate-to-severe plaque psoriasis had both CD4+ and CD8+ LL-37-reactive T cells, implying that LL-37 (Cap-18) pre mixed peptide may influence the activation of these immune cells [4].
In addition to immunomodulatory effects, LL-37 (cap-18) pre mixed peptide exhibits angiogenic activities, encouraging the formation of new blood vessels via formyl peptide receptor-like 1 expressed on endothelial cells [5]. This discovery brings up new therapeutic possibilities in wound healing and tissue regeneration.
It has also been investigated how LL-37 (cap-18) pre mixed peptide interacts with lipid bilayers. Despite being highly charged, LL-37 interacts with lipid bilayers in a variety of ways depending on their composition, which may influence its antibacterial action [6].
Interestingly, France research has demonstrated that the LL-37 (cap-18) pre mixed peptide can decrease HIV-1 replication, implying that it could be used in antiviral therapy. Furthermore, LL-37’s antibacterial activity has been shown to be conformation-dependent, shedding light on the structural basis of its function [7].
[1] https://journals.aai.org/jimmunol/ article/191/10/4895/86783
[2] https://journals.aai.org/jimmunol/ article/169/7/3883/35412
[3] https://journals.asm.org/doi/full/ 10.1128/iai.00318-08
[4] https://www.mdpi.com/ 2076-393X/8/3/517
[5] https://www.jci.org/ articles/view/17545
[6] https://pubs.acs.org/doi/abs/ 10.1021/bi0273563
[7] https://www.jbc.org/article/ S0021-9258(18)93785-3/fulltext
Sequence: Leu Leu Gly Asp-Phe-Phe Arg Lys-Ser Lys-Glu Lys.11e-Gly Lys Glu Phe Lys-Arg Ile Val-Gln Are Ile-Lys Asp Phe Leu Arg Asn Leu Val Pro-Arg Thr-Glu-Ser
Molecular Formula: C205 H340 N60 O53
Molecular Weight: 4493.342 g/mol
Storage: Lyophilized peptides to be stored below -18°C
Research use only. Not for human or animal consumption!
ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.
DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our France Direct Peptides website: https://france.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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